SIMULTANEOUS ANALYSIS OF RPHPLC METHOD DEVELOPMENT AND VALIDATION OF TERBINAFINE AND BEZAFIBRATE DRUGS IN PHARMACEUTICAL DOSAGE FORM Available online at http://www.pharmacophorejournal.com/
نویسندگان
چکیده
A simple, sensitive and accurate reversed phase high performance liquid chromatographic method for terbinafine and bezafibrate drugs. This method is developed for terbinafine and bezafibrate drugs. Reversed phase chromatographic separation of the two drugs was performed a C18 column is used with different mobile phases of methanol, water, ammonium dihydrogen phosphate and methanol, acetonitrile, orthophosphoric acid respectively. The detection of wave length is 225 nm for terbinafine and 232 nm for bezafibrate. The percentage of recovery 99.51% for terbinafine and 99.94% for bezafibrate. The proposed method is validated for linearity, accuracy and precision, limit of detection (LOD) and limit of quantification (LOQ) as per the guide lines of International Conference on Harmonization (ICH).
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